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Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

Difficulty with Detoxification: Impaired methylation affects the bodys ability to detoxify harmful substances effectively

Both serum and plasma samples in which EDTA has been used as the anticoagulant can be used for all the B12 analytical methods

doi: 10.1038/s41598-017-15668-z 104 ZouYHenryWSRicqELGrahamETPhadnisVVMaretichPet al